Comparative efficacy of anti-CD40 antibody-mediated costimulation blockade on long-term survival of full-thickness porcine corneal grafts in nonhuman primates.

Kim, Jaeyoung; Choi, Se Hyun; Lee, Hyun Ju; Kim, Hong Pyo; Kang, Hee Jung; Kim, Jong Min; Hwang, Eung Soo; Park, Chung-Gyu; Kim, Mee Kum

Kim, Jaeyoung; Choi, Se Hyun; Lee, Hyun Ju; Kim, Hong Pyo; Kang, Hee Jung; Kim, Jong Min; Hwang, Eung Soo; Park, Chung-Gyu; Kim, Mee Kum.

Afiliação

Kim J; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Choi SH; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Lee HJ; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Kim HP; Translational Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Kang HJ; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Kim JM; Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Hwang ES; Translational Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.
Park CG; Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Gyeonggi-do, Korea.
Kim MK; Translational Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.

Am J Transplant ; 18(9): 2330-2341, 2018 09.

Article em En | MEDLINE | ID: mdl-29722120

Assuntos

Anticorpos Monoclonais/farmacologia; Antígenos CD40/antagonistas & inibidores; Transplante de Córnea; Rejeição de Enxerto/prevenção & controle; Sobrevivência de Enxerto/efeitos dos fármacos; Doadores de Tecidos; Animais; Antígenos CD40/imunologia; Feminino; Macaca mulatta; Suínos; Transplante Heterólogo

Palavras-chave

animal models: nonhuman primate; animal models: porcine; clinical research/practice; corneal transplantation/ophthalmology; graft survival; immunosuppressant - fusion proteins and monoclonal antibodies: B cell specific; immunosuppressant - fusion proteins and monoclonal antibodies: costimulation molecule specific; xenotransplantation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Transplante de Córnea / Antígenos CD40 / Rejeição de Enxerto / Sobrevivência de Enxerto / Anticorpos Monoclonais Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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