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Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II.
Nicolas, Xavier; Djebli, Nassim; Rauch, Clémence; Brunet, Aurélie; Hurbin, Fabrice; Martinez, Jean-Marie; Fabre, David.
Afiliação
  • Nicolas X; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France. xavier.nicolas@sanofi.com.
  • Djebli N; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
  • Rauch C; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
  • Brunet A; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
  • Hurbin F; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
  • Martinez JM; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
  • Fabre D; TMED/PKDM Department, Sanofi, 371 Rue du Professeur Joseph Blayac, 34184, Montpellier Cedex 04, France.
Clin Pharmacokinet ; 58(1): 115-130, 2019 01.
Article em En | MEDLINE | ID: mdl-29725997
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Anticorpos Monoclonais Humanizados / Hipercolesterolemia / Modelos Biológicos / Anticolesterolemiantes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Anticorpos Monoclonais Humanizados / Hipercolesterolemia / Modelos Biológicos / Anticolesterolemiantes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article