The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies.
Reprod Toxicol
; 80: 126-130, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29729334
ABSTRACT
In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Hormônios Tireóideos
/
Guias como Assunto
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Testes de Toxicidade
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Técnicas de Laboratório Clínico
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Disruptores Endócrinos
Tipo de estudo:
Diagnostic_studies
/
Guideline
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Qualitative_research
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article