Evaluation of a new continuous mononuclear cell collection procedure in a single transplant center cohort enriched for AL amyloidosis patients.
Transfus Apher Sci
; 57(3): 411-415, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29731423
ABSTRACT
BACKGROUND:
The Spectra Optia continuous mononuclear cell (CMNC) program is newly available, and herein validated in a single-center cohort enriched with AL amyloidosis patients to collect a target CD34+ yield of 2.5â¯×â¯106 cells/kg within 2 days.METHODS:
Consecutive autologous transplant patients in 2016 are included. Patients undergo leukapheresis with Optia CMNC and Spectra v4.7 over a 2-day cycle. Data collection includes collection efficiency, adverse events and engraftment kinetics.RESULTS:
36 leukapheresis procedures on 18 patients are included. The diagnoses are AL amyloidosis (9), myeloma (7), lymphoma (2), and scleroderma (1). Median age is 60; 12 are men. Plerixafor was employed pre-emptively in 6 cycles. Median blood CD34+ on Day 1 of leukapheresis was 46 cells/uL. Median number of blood volumes processed on Day 1 was 3.1. All collection cycles were completed within 2 days; only one in a heavily pretreated lymphoma patient did not reach the target requiring a second mobilization attempt. Mean collection efficiencies were comparable between the two devices. There were 2 adverse events tubing rupture on the Optia; and one case of hypotension. All 18 patients underwent high-dose chemotherapy median cell dose infused was 7.7â¯×â¯106 CD34+ cells/kg. Median days to neutrophil and platelet engraftment were 10 and 13 respectively.CONCLUSION:
The Optia CMNC collection protocol is safe and effective in a small single-center autologous stem cell transplant cohort enriched for high-risk patients with AL amyloidosis and cardiac involvement. Caution is needed for tubing setup because there is less cumulative experience with Optia.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Leucaférese
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Amiloidose de Cadeia Leve de Imunoglobulina
Tipo de estudo:
Guideline
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article