Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments.

Galmozzi, Andrea; Parker, Christopher G; Kok, Bernard P; Cravatt, Benjamin F; Saez, Enrique

Galmozzi, Andrea; Parker, Christopher G; Kok, Bernard P; Cravatt, Benjamin F; Saez, Enrique.

Afiliação

Galmozzi A; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. galmozzi@scripps.edu.
Parker CG; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Kok BP; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Cravatt BF; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
Saez E; Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

Methods Mol Biol ; 1787: 115-127, 2018.

Article em En | MEDLINE | ID: mdl-29736714

Assuntos

Adipócitos/efeitos dos fármacos; Adipócitos/fisiologia; Descoberta de Drogas; Células 3T3-L1; Adipogenia/efeitos dos fármacos; Animais; Descoberta de Drogas/métodos; Avaliação Pré-Clínica de Medicamentos; Variação Genética; Humanos; Espectrometria de Massas; Camundongos; Fenótipo; Proteoma; Proteômica/métodos; Bibliotecas de Moléculas Pequenas; Tiazolidinedionas/farmacologia

Palavras-chave

Adipogenesis; Adipose tissue; Chemical proteomics; Phenotypic screening; Photoreactive small molecules; Target identification

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adipócitos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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