A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers.
Bioanalysis
; 10(9): 645-657, 2018 May 01.
Article
em En
| MEDLINE
| ID: mdl-29749252
ABSTRACT
AIM:
Selected bile acids (BAs) in plasma have been proposed as endogenous probes for assessing drug-drug interactions involving hepatic drug transporters such as the organic anion-transporting polypeptides (OATP1B1 and OATP1B3). MATERIALS &METHODS:
Plasma extracts were analyzed for selected BAs using a triple TOF API6600 high-resolution mass spectrometer.RESULTS:
Glycodeoxycholic acid 3-sulfate, glycochenodeoxycholic acid 3-sulfate, glycodeoxycholic acid 3-O-ß-glucuronide and glycochenodeoxycholic acid 3-O-ß-glucuronide are presented as potential OATP1B1/3 biomarkers.CONCLUSION:
Six BAs are quantified in human plasma using a multiplexed high-resolution mass spectrometry method. Glycodeoxycholic acid 3-sulfate and glycodeoxycholic acid 3-O-ß-glucuronide are proposed as potential biomarkers based on observed four- to fivefold increase in plasma AUC (vs placebo), following administration of a compound known to present as an OATP1B1/3 inhibitor in vitro.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transportador 1 de Ânion Orgânico Específico do Fígado
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Biomarcadores Farmacológicos
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Membro 1B3 da Família de Transportadores de Ânion Orgânico Carreador de Soluto
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Ácido Glicodesoxicólico
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article