LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

Siroká, Jitka; Cecková, Martina; Urbánek, Lubor; Krystof, Vladimír; Gucký, Tomás; Hofman, Jakub; Strnad, Miroslav; Staud, Frantisek

Siroká, Jitka; Cecková, Martina; Urbánek, Lubor; Krystof, Vladimír; Gucký, Tomás; Hofman, Jakub; Strnad, Miroslav; Staud, Frantisek.

Afiliação

Siroká J; Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Institute of Experimental Botany ASCR, Slechtitelu 27, CZ-783 71 Olomouc, Czech Republic. Electronic address: sirokajitka@gmail.com.
Cecková M; Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Heyrovského 1203, Hradec Králové, Czech Republic.
Urbánek L; Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Institute of Experimental Botany ASCR, Slechtitelu 27, CZ-783 71 Olomouc, Czech Republic.
Krystof V; Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Institute of Experimental Botany ASCR, Slechtitelu 27, CZ-783 71 Olomouc, Czech Republic.
Gucký T; Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Institute of Experimental Botany ASCR, Slechtitelu 27, CZ-783 71 Olomouc, Czech Republic.
Hofman J; Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Heyrovského 1203, Hradec Králové, Czech Republic.
Strnad M; Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Palacký University, Institute of Experimental Botany ASCR, Slechtitelu 27, CZ-783 71 Olomouc, Czech Republic.
Staud F; Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacology and Toxicology, Heyrovského 1203, Hradec Králové, Czech Republic.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1089: 24-32, 2018 Jul 01.

Article em En | MEDLINE | ID: mdl-29753211

Assuntos

2-Aminopurina/análogos & derivados; Antineoplásicos/análise; Antineoplásicos/química; Ciclinas/química; Espectrometria de Massas em Tandem/métodos; 2-Aminopurina/análise; 2-Aminopurina/farmacocinética; Administração Intravenosa/métodos; Animais; Antineoplásicos/administração & dosagem; Antineoplásicos/farmacocinética; Disponibilidade Biológica; Calibragem; Cromatografia Líquida de Alta Pressão/métodos; Eliminação Hepatobiliar/efeitos dos fármacos; Humanos; Limite de Detecção; Masculino; Estrutura Molecular; Inibidores de Proteínas Quinases/administração & dosagem; Inibidores de Proteínas Quinases/análise; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacocinética; Ratos; Ratos Wistar; Reprodutibilidade dos Testes; Relação Estrutura-Atividade; Distribuição Tecidual/efeitos dos fármacos

Palavras-chave

BP-14; BP-20; Cyclin-dependent kinase inhibitor; Pharmacokinetics; Tissue distribution

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciclinas / Espectrometria de Massas em Tandem / 2-Aminopurina / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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