Synchronous Chemoradiation Nanovesicles by X-Ray Triggered Cascade of Drug Release.
Angew Chem Int Ed Engl
; 57(28): 8463-8467, 2018 07 09.
Article
em En
| MEDLINE
| ID: mdl-29757483
ABSTRACT
The approach of concurrent-to-synchronous chemoradiation has now been advanced by well-designed nanovesicles that permit X-ray irradiation-triggered instant drug release. The nanovesicles consist of Au nanoparticles tethered with irradiation labile linoleic acid hydroperoxide (LAHP) molecules and oxidation-responsive poly(propylene sulfide)-poly(ethylene glycol) (PPS-PEG) polymers, where DOX were loaded in the inner core of the vesicles (Au-LAHP-vDOX). Upon irradiation, the inâ
situ formation of hydroxyl radicals from LAHP molecules triggers the internal oxidation of PPS from being hydrophobic to hydrophilic, leading to degradation of the vesicles and burst release of cargo drugs. In this manner, synchronous chemoradiation showed impressive anticancer efficacy both in vitro and in a subcutaneous mouse tumor model by one-dose injection and one-time irradiation.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Raios X
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Portadores de Fármacos
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Nanopartículas
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Liberação Controlada de Fármacos
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Ouro
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Antibióticos Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article