Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: confirmation of a very recently described rhabdomyosarcoma subtype.
Histopathology
; 73(3): 514-520, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29758589
ABSTRACT
AIMS:
Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harbouring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has been reported very recently. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL ANDRESULTS:
A previously well 72-year-old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma. RNA-seq, RT-PCR and FISH confirmed the presence of the FUS-TFCP2 fusion.CONCLUSIONS:
Spindle cell rhabdomyosarcomas carrying the FUS-TFCP2 fusion are very rare rhabdomyosarcoma variants with osseous predilection. The classification and differential diagnosis of this unusual molecular variant of spindle cell/sclerosing rhabdomyosarcoma are discussed.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Rabdomiossarcoma
/
Fatores de Transcrição
/
Neoplasias Mandibulares
/
Proteínas de Fusão Oncogênica
/
Proteína FUS de Ligação a RNA
/
Proteínas de Ligação a DNA
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article