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Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors.
Rodrigues, Manuel; Mobuchon, Lenha; Houy, Alexandre; Fiévet, Alice; Gardrat, Sophie; Barnhill, Raymond L; Popova, Tatiana; Servois, Vincent; Rampanou, Aurore; Mouton, Aurore; Dayot, Stéphane; Raynal, Virginie; Galut, Michèle; Putterman, Marc; Tick, Sarah; Cassoux, Nathalie; Roman-Roman, Sergio; Bidard, François-Clément; Lantz, Olivier; Mariani, Pascale; Piperno-Neumann, Sophie; Stern, Marc-Henri.
Afiliação
  • Rodrigues M; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Mobuchon L; Department of Medical Oncology, Institut Curie, PSL Research University, Paris, 75248, France.
  • Houy A; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Fiévet A; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Gardrat S; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Barnhill RL; Department of Genetics, Institut Curie, PSL Research University, Paris, 75248, France.
  • Popova T; Department of Biopathology, Institut Curie, PSL Research University, Paris, 75248, France.
  • Servois V; Department of Biopathology, Institut Curie, PSL Research University, Paris, 75248, France.
  • Rampanou A; Faculty of Medicine, University of Paris Descartes, Paris, 75006, France.
  • Mouton A; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Dayot S; Department of Medical Imaging, Institut Curie, PSL Research University, Paris, 75248, France.
  • Raynal V; Institut Curie, PSL Research University, Laboratory of Circulating Tumor Biomarkers, SiRIC, Paris, 75248, France.
  • Galut M; Institut Curie, PSL Research University, INSERM CIC-BT 1428, Paris, 75248, France.
  • Putterman M; Institut Curie, PSL Research University, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, 75248, France.
  • Tick S; Institut Curie, PSL Research University, INSERM U830 and Institut Curie Genomics of Excellence (ICGex) Platform, Paris, 75248, France.
  • Cassoux N; Institut Curie, PSL Research University, Biological Resource Center, Paris, 75248, France.
  • Roman-Roman S; Department of Pathology, Quinze-Vingts National Ophthalmology Hospital, Paris, 75012, France.
  • Bidard FC; Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, Paris, 75012, France.
  • Lantz O; Faculty of Medicine, University of Paris Descartes, Paris, 75006, France.
  • Mariani P; Department of Ocular Oncology, Institut Curie, PSL Research University, Paris, 75248, France.
  • Piperno-Neumann S; Department of Translational Research, Institut Curie, PSL Research University, Paris, 75248, France.
  • Stern MH; Department of Medical Oncology, Institut Curie, PSL Research University, Paris, 75248, France.
Nat Commun ; 9(1): 1866, 2018 05 14.
Article em En | MEDLINE | ID: mdl-29760383
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uveais / Mutação em Linhagem Germinativa / Endodesoxirribonucleases / Anticorpos Monoclonais Humanizados / Receptor de Morte Celular Programada 1 / Antineoplásicos Imunológicos / Melanoma Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uveais / Mutação em Linhagem Germinativa / Endodesoxirribonucleases / Anticorpos Monoclonais Humanizados / Receptor de Morte Celular Programada 1 / Antineoplásicos Imunológicos / Melanoma Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article