Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.

Weir, Mark C; Shu, Sherry T; Patel, Ravi K; Hellwig, Sabine; Chen, Li; Tan, Li; Gray, Nathanael S; Smithgall, Thomas E

Weir, Mark C; Shu, Sherry T; Patel, Ravi K; Hellwig, Sabine; Chen, Li; Tan, Li; Gray, Nathanael S; Smithgall, Thomas E.

Afiliação

Weir MC; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.
Shu ST; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.
Patel RK; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.
Hellwig S; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.
Chen L; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.
Tan L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology , Dana-Farber Cancer Institute , 250 Longwood Avenue , Boston , Massachusetts 02115 , United States.
Gray NS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology , Dana-Farber Cancer Institute , 250 Longwood Avenue , Boston , Massachusetts 02115 , United States.
Smithgall TE; Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Pittsburgh , Pennsylvania , United States.

ACS Chem Biol ; 13(6): 1551-1559, 2018 06 15.

Article em En | MEDLINE | ID: mdl-29763550

Assuntos

Antineoplásicos/uso terapêutico; Benzamidas/uso terapêutico; Leucemia Mieloide Aguda/tratamento farmacológico; Inibidores de Proteínas Quinases/uso terapêutico; Proteínas Proto-Oncogênicas/antagonistas & inibidores; Quinazolinas/uso terapêutico; Quinases da Família src/antagonistas & inibidores; Administração Oral; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Antineoplásicos/administração & dosagem; Apoptose/efeitos dos fármacos; Benzamidas/administração & dosagem; Linhagem Celular Tumoral; Feminino; Humanos; Masculino; Camundongos; Pessoa de Meia-Idade; Inibidores de Proteínas Quinases/administração & dosagem; Proteínas Proto-Oncogênicas c-hck/antagonistas & inibidores; Quinazolinas/administração & dosagem; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Benzamidas / Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas / Quinases da Família src / Inibidores de Proteínas Quinases / Antineoplásicos Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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