Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.

Mo, Lijun; Zhang, Xinji; Shi, Xiaojun; Wei, Lili; Zheng, Dianpeng; Li, Hongwei; Gao, Jimin; Li, Jinlong; Hu, Zhiming

Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.

Mo, Lijun; Zhang, Xinji; Shi, Xiaojun; Wei, Lili; Zheng, Dianpeng; Li, Hongwei; Gao, Jimin; Li, Jinlong; Hu, Zhiming.

Afiliação

Mo L; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Zhang X; Department of Urology, Shunde Hospital, Southern Medical University, Guangzhou, China.
Shi X; Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wei L; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Zheng D; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Li H; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Gao J; Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical University, Wenzhou, China.
Li J; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Hu Z; Institute of Biotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.

Cancer Sci ; 109(7): 2109-2118, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29770533

Assuntos

Antineoplásicos/farmacologia; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Vacinas Anticâncer/farmacologia; Neoplasias da Próstata/imunologia; Linfócitos T Reguladores/efeitos dos fármacos; Animais; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia; Humanos; Linfócitos do Interstício Tumoral/efeitos dos fármacos; Linfócitos do Interstício Tumoral/imunologia; Masculino; Camundongos

Palavras-chave

Tregs; cancer immunotherapy; mGM-CSF vaccine; norcantharidin; prostate cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Linfócitos T Reguladores / Compostos Bicíclicos Heterocíclicos com Pontes / Vacinas Anticâncer / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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