Mental-orientation: A new approach to assessing patients across the Alzheimer's disease spectrum.
Neuropsychology
; 32(6): 690-699, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-29781630
ABSTRACT
OBJECTIVE:
This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task.METHOD:
A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology.RESULTS:
The mental-orientation task differentiated mild cognitively impaired and healthy controls at 95% accuracy, while the Addenbrooke's Cognitive Examination, Mini-Mental State Examination and standard-orientation achieved 74%, 70% and 50% accuracy, respectively. Functional MRI revealed the mental-orientation task to preferentially recruit brain regions exhibiting early Alzheimer's-related atrophy, unlike the standard-orientation test.CONCLUSIONS:
Mental-orientation is suggested to play a key role in Alzheimer's disease, and consequently in early detection and follow-up of patients along the Alzheimer's disease spectrum. (PsycINFO Database Record
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Orientação
/
Doença de Alzheimer
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Disfunção Cognitiva
/
Testes Neuropsicológicos
Tipo de estudo:
Screening_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article