Endurance training alters YKL40, PERM1, and HSP70 skeletal muscle protein contents in men with type 2 diabetes mellitus.
Endocr Res
; 44(1-2): 1-8, 2019.
Article
em En
| MEDLINE
| ID: mdl-29781744
ABSTRACT
BACKGROUND:
The fight against type 2 diabetes mellitus (T2DM) is tremendously challenging. This pilot study investigates whether endurance training (3 times per week for 3 months, moderate intensity) can change the skeletal muscle protein contents of chitinase-3-like protein-1 (YKL40), peroxisome proliferator-activated receptor y coactivator-1 and estrogen-related receptor-induced regulator in muscle-1 (PERM1) and heat-shock protein-70 (HSP70), which have been discussed as novel therapeutically relevant targets.METHODS:
Muscle biopsies were obtained from overweight/obese men with T2DM (n = 7, years = 63 ± 9) at T1 (6 weeks pre-training), T2 (1 week pre-training) and T3 (3 to 4 days post-training). The protein levels of YKL40, PERM1, and HSP70 were determined by immunohistochemistry.RESULTS:
YKL40, PERM1, and HSP70 were significantly upregulated following endurance training (T2-T3 +103%, +61%, +89%, p = 0.012, p = 0.010, p = 0.028). There was a fiber type-specific distribution of HSP70 with increased protein contents in type I fibers. A significant change in the fiber type distribution with an increase in type I fibers and a decrease in type II fibers was observed post-training. There were no significant differences for YKL40, PERM1, HSP70, or the fiber type distribution between T1 and T2.CONCLUSION:
The training-induced upregulation of YKL40, PERM1, and HSP70 could help manage the diabetic disease and reduce its complications.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibras Musculares Esqueléticas
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Proteínas de Choque Térmico HSP70
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Diabetes Mellitus Tipo 2
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Sobrepeso
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Proteína 1 Semelhante à Quitinase-3
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Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo
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Treino Aeróbico
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article