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CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
Glass, Sarah M; Martell, Cydney M; Oswalt, Alexandria K; Osorio-Vasquez, Victoria; Cho, Christi; Hicks, Michael J; Mills, Jacqueline M; Fujiwara, Rina; Glista, Michael J; Kamath, Sharat S; Furge, Laura Lowe.
Afiliação
  • Glass SM; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Martell CM; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Oswalt AK; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Osorio-Vasquez V; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Cho C; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Hicks MJ; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Mills JM; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Fujiwara R; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Glista MJ; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Kamath SS; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
  • Furge LL; Department of Chemistry, Kalamazoo College, Kalamazoo, Michigan Laura.Furge@kzoo.edu.
Drug Metab Dispos ; 46(8): 1106-1117, 2018 08.
Article em En | MEDLINE | ID: mdl-29784728
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Citocromo P-450 CYP2D6 / Dextrometorfano / Etanolaminas / Imidazóis / Mutação / NADP Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Citocromo P-450 CYP2D6 / Dextrometorfano / Etanolaminas / Imidazóis / Mutação / NADP Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article