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Total Synthesis of the Marine Phosphomacrolide, (-)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis-Ferrier Union/Rearrangement.
Ai, Yanran; Kozytska, Mariya V; Zou, Yike; Khartulyari, Anton S; Maio, William A; Smith, Amos B.
Afiliação
  • Ai Y; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Kozytska MV; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Zou Y; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Khartulyari AS; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Maio WA; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Smith AB; Department of Chemistry, Laboratory for Research on the Structure of Matter, and Monell Chemical Senses Center , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
J Org Chem ; 83(11): 6110-6126, 2018 06 01.
Article em En | MEDLINE | ID: mdl-29786446
ABSTRACT
An effective late-stage large-fragment union/rearrangement exploiting the Petasis-Ferrier protocol, in conjunction with multicomponent Type I Anion Relay Chemistry (ARC) to access advanced intermediates, permits completion of a convergent, stereocontrolled total synthesis of the architecturally complex phosphomacrolide (-)-enigmazole A (1).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Oxazóis / Macrolídeos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Organofosforados / Oxazóis / Macrolídeos Idioma: En Ano de publicação: 2018 Tipo de documento: Article