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Clinical and Cardiac Safety of Long-term Levofloxacin in Children Treated for Multidrug-resistant Tuberculosis.
Garcia-Prats, Anthony J; Draper, Heather R; Finlayson, Heather; Winckler, Jana; Burger, André; Fourie, Barend; Thee, Stephanie; Hesseling, Anneke C; Schaaf, H Simon.
Afiliação
  • Garcia-Prats AJ; Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
  • Draper HR; Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
  • Finlayson H; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University.
  • Winckler J; Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
  • Burger A; Brewelskloof Hospital, Western Cape Government Department of Health, Worcester, South Africa.
  • Fourie B; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University.
  • Thee S; Department of Paediatric Pneumology and Immunology, Charité, Universitätsmedizin Berlin, Germany.
  • Hesseling AC; Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
  • Schaaf HS; Desmond Tutu TB Centre, Department of Paediatrics and Child Health.
Clin Infect Dis ; 67(11): 1777-1780, 2018 11 13.
Article em En | MEDLINE | ID: mdl-29788331
ABSTRACT
Safety concerns persist for long-term pediatric fluoroquinolone use. Seventy children (median age, 2.1 years) treated with levofloxacin 10-20 mg/kg once daily for multidrug-resistant tuberculosis (median observation time, 11.8 months) had few musculoskeletal events, no levofloxacin-attributed serious adverse events, and no Fridericia-corrected QT interval >450 ms. Long-term levofloxacin was safe and well tolerated.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Levofloxacino / Coração / Antituberculosos Tipo de estudo: Observational_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Resistente a Múltiplos Medicamentos / Levofloxacino / Coração / Antituberculosos Tipo de estudo: Observational_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male País como assunto: Africa Idioma: En Ano de publicação: 2018 Tipo de documento: Article