Your browser doesn't support javascript.
loading
Effects of alcohol exposure on the glutamatergic system: a combined longitudinal 18 F-FPEB and 1 H-MRS study in rats.
de Laat, Bart; Weerasekera, Akila; Leurquin-Sterk, Gil; Gsell, Willy; Bormans, Guy; Himmelreich, Uwe; Casteels, Cindy; Van Laere, Koen.
Afiliação
  • de Laat B; KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
  • Weerasekera A; KU Leuven - University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Belgium.
  • Leurquin-Sterk G; KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
  • Gsell W; KU Leuven - University of Leuven, Biomedical MRI unit, Department of Imaging and Pathology, Belgium.
  • Bormans G; KU Leuven - University of Leuven/University Hospital Leuven, Division of Nuclear Medicine, Department of Imaging and Pathology, Belgium.
  • Himmelreich U; KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
  • Casteels C; KU Leuven - University of Leuven, Biomedical MRI unit, Department of Imaging and Pathology, Belgium.
  • Van Laere K; KU Leuven - University of Leuven, MoSAIC, Molecular Small Animal Imaging Center, Belgium.
Addict Biol ; 24(4): 696-706, 2019 07.
Article em En | MEDLINE | ID: mdl-29790622
In a longitudinal rat model of alcohol consumption, we showed that exposure to alcohol decreased the concentration of glutamate in the prefrontal cortex, whereas a normalization occurred during abstinence. 18F-FPEB PET scans revealed that pre-exposure mGluR5 availability in the nucleus accumbens was associated with future alcohol preference. Finally, alcohol exposure induced a decrease in mGluR5 availability in the bilateral hippocampus and amygdala compared with baseline, and in the hippocampus and striatum compared with saccharin (Figure).
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Depressores do Sistema Nervoso Central / Córtex Pré-Frontal / Etanol / Receptor de Glutamato Metabotrópico 5 / Hipocampo / Tonsila do Cerebelo / Núcleo Accumbens Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Depressores do Sistema Nervoso Central / Córtex Pré-Frontal / Etanol / Receptor de Glutamato Metabotrópico 5 / Hipocampo / Tonsila do Cerebelo / Núcleo Accumbens Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article