Effects of acute and chronic exposures of fluoxetine on the Chinese fish, topmouth gudgeon Pseudorasbora parva.
Ecotoxicol Environ Saf
; 160: 104-113, 2018 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-29793199
ABSTRACT
Fluoxetine is a selective serotonin reuptake inhibitor used as an antidepressant and has been frequently detected in aquatic environments. However, its effects in fish from Asia remain relatively less studied. In this study, the topmouth gudgeon Pseudorasbora parva was exposed to 0, 50, and 200⯵g/L of fluoxetine for 4â¯h and 42 d. The effects of fluoxetine on biometrics were compared to biochemical endpoints indicative of stress in different fish tissues (brain, liver, gills and intestine) following exposures. In fish exposed for 42 d, lipid peroxidation endpoints were enhanced 80% in the liver and gills. Acetylcholinesterase (AChE) activity was increased 40% after exposure to 50⯵g/L and 55% at 200⯵g/L following 4â¯h exposure. In contrast AChE was increased 26% (at 50⯵g/L) after 42 d of exposures. Enhanced ethoxyresorufin-O-deethylase activity (EROD) was detected only in fish exposed to 50⯵g/L of fluoxetine for 4â¯h. The activity of α-glucosidase (α-Glu) was also induced (at 200⯵g/L) after 4â¯h of exposure. After 4â¯h of exposure, the activities of proteases in the intestine were generally inhibited at 200⯵g/L. Both 4â¯h and 42 d exposures resulted in an increased hepatosomatic index (HSI) but did not affect the condition factor (CF). Our results demonstrate that fluoxetine significantly altered biochemical endpoints in P. parva after acute exposure and the morphological changes in liver size were not observed until 42â¯d of exposure.
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MEDLINE
Assunto principal:
Poluentes Químicos da Água
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Cyprinidae
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Fluoxetina
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Inibidores Seletivos de Recaptação de Serotonina
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Antidepressivos de Segunda Geração
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article