Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells.

Bhattacharyya, Sumit; Feferman, Leo; Han, Xiaorui; Ouyang, Yilan; Zhang, Fuming; Linhardt, Robert J; Tobacman, Joanne K

Bhattacharyya, Sumit; Feferman, Leo; Han, Xiaorui; Ouyang, Yilan; Zhang, Fuming; Linhardt, Robert J; Tobacman, Joanne K.

Afiliação

Bhattacharyya S; From the Department of Medicine, University of Illinois and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and.
Feferman L; From the Department of Medicine, University of Illinois and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and.
Han X; the Departments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology and Biomedical Engineering and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Ouyang Y; the Departments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology and Biomedical Engineering and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Zhang F; the Departments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology and Biomedical Engineering and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Linhardt RJ; the Departments of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology and Biomedical Engineering and the Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180.
Tobacman JK; From the Department of Medicine, University of Illinois and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612 and jkt@uic.edu.

J Biol Chem ; 293(28): 11076-11087, 2018 07 13.

Article em En | MEDLINE | ID: mdl-29794138

Assuntos

Células Epiteliais/metabolismo; MAP Quinase Quinase 4/metabolismo; N-Acetilgalactosamina-4-Sulfatase/metabolismo; Próstata/metabolismo; Proteína Tirosina Fosfatase não Receptora Tipo 11/antagonistas & inibidores; Células-Tronco/metabolismo; Sulfatos de Condroitina/metabolismo; Células Epiteliais/citologia; Receptores ErbB/genética; Receptores ErbB/metabolismo; Humanos; MAP Quinase Quinase 4/genética; Masculino; N-Acetilgalactosamina-4-Sulfatase/genética; Fosforilação; Próstata/citologia; Neoplasias da Próstata/metabolismo; Neoplasias da Próstata/patologia; Transdução de Sinais; Células-Tronco/citologia

Palavras-chave

N-acetylgalactosamine-4-sulfatase; PTPN11; Src homology 2 domain (SH2 domain); arylsulfatase B; c-Fos; c-Jun N-terminal kinase (JNK); c-Jun transcription factor; chondroitin sulfate; epidermal growth factor receptor (EGFR); phosphoprotein phosphatase; prostate; stem cells; transcription factor AP-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Próstata / Células-Tronco / N-Acetilgalactosamina-4-Sulfatase / MAP Quinase Quinase 4 / Células Epiteliais / Proteína Tirosina Fosfatase não Receptora Tipo 11 Limite: Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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