Formal [4 + 2] cycloaddition of imines with alkoxyisocoumarins.
Org Biomol Chem
; 16(23): 4231-4235, 2018 06 13.
Article
em En
| MEDLINE
| ID: mdl-29796555
ABSTRACT
A new preparation of δ-lactams is reported. In the presence of a Lewis acid promoter, alkoxyisocoumarins engage a range of N-aryl and N-alkyl imines to form δ-lactams with a pendent carboalkoxy substituent. A sulfonamide-thiourea catalyst enables the synthesis of these products in moderate to good enantioselectivities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isocumarinas
/
Iminas
/
Lactamas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article