What is new in the epidemiology and pathogenesis of peptic ulcer?
Aliment Pharmacol Ther
; 1 Suppl 1: 510S-517S, 1987.
Article
em En
| MEDLINE
| ID: mdl-2979699
ABSTRACT
The old dictum 'no acid--no ulcer' is no longer a sufficient explanation of the pathogenesis of ulcer disease. The real question is 'if acid--why ulcer?' Although acid remains predominant, some of the other factors influencing ulcerogenesis are nocturnal acid secretion, pepsin enzyme subspecies, the mucus layer, bicarbonate levels, prostaglandins, Campylobacter pylori infection, consumption of non-steroidal anti-inflammatory drugs, and smoking habits. Although the ulcer burden has been greatly reduced by the introduction of H2-receptor antagonists, complications such as bleeding and perforation remain a problem, especially in the elderly. Medical treatment, in the form of H2-receptor antagonists, is effective for many patients.
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Base de dados:
MEDLINE
Assunto principal:
Úlcera Péptica
Tipo de estudo:
Etiology_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article