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Synthesis of gem-Difluorinated Spiro-γ-lactam Oxindoles by Visible-Light-Induced Consecutive Difluoromethylative Dearomatization, Hydroxylation, and Oxidation.
Wang, Qiang; Qu, Yi; Xia, Qing; Song, Hongjian; Song, Haibin; Liu, Yuxiu; Wang, Qingmin.
Afiliação
  • Wang Q; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Qu Y; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Xia Q; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Song H; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Song H; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Liu Y; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
  • Wang Q; State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Collaborative Innovation Center of, Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, 300071, P. R. China.
Chemistry ; 24(44): 11283-11287, 2018 Aug 06.
Article em En | MEDLINE | ID: mdl-29797623
ABSTRACT
Described herein is a protocol for visible-light-induced consecutive synthesis of gem-difluorinated spiro-γ-lactam oxindoles under mild conditions by means of a process involving sequential radical difluoromethylative dearomatization, hydroxylation, and oxidation. The protocol features high chemo- and regioselectivity, good functional group tolerance, and easy scalability. Several of the functionalized spirooxindole products showed good fungicidal activity, suggesting that they have potential agrochemical applications.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article