Your browser doesn't support javascript.
loading
An ingestible bacterial-electronic system to monitor gastrointestinal health.
Mimee, Mark; Nadeau, Phillip; Hayward, Alison; Carim, Sean; Flanagan, Sarah; Jerger, Logan; Collins, Joy; McDonnell, Shane; Swartwout, Richard; Citorik, Robert J; Bulovic, Vladimir; Langer, Robert; Traverso, Giovanni; Chandrakasan, Anantha P; Lu, Timothy K.
Afiliação
  • Mimee M; Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Nadeau P; Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.
  • Hayward A; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
  • Carim S; Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA.
  • Flanagan S; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
  • Jerger L; Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.
  • Collins J; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
  • McDonnell S; Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.
  • Swartwout R; Division of Pediatric Gastroentrology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA 02114, USA.
  • Citorik RJ; Harvard Medical School, Boston, MA 02115, USA.
  • Bulovic V; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
  • Langer R; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
  • Traverso G; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
  • Chandrakasan AP; Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Lu TK; Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.
Science ; 360(6391): 915-918, 2018 05 25.
Article em En | MEDLINE | ID: mdl-29798884
ABSTRACT
Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Probióticos / Trato Gastrointestinal / Gastroenteropatias / Monitorização Fisiológica Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas Biossensoriais / Probióticos / Trato Gastrointestinal / Gastroenteropatias / Monitorização Fisiológica Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article