Optimal body mass index cut-off points for prediction of incident diabetes in a Chinese population.
J Diabetes
; 10(12): 926-933, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-29802755
ABSTRACT
BACKGROUND:
The current body mass index (BMI) classifications have been established based on the risk of obesity-related conditions, but not specifically on type 2 diabetes mellitus (T2DM). The aim of this study was to identify the optimal BMI cut-off points for assessing incident T2DM risk in the Chinese population.METHODS:
The longitudinal study cohort consisted of 8735 non-diabetic participants aged 20-74 years at baseline, with a mean follow-up period of 6.0 years. Body mass index, 2-h plasma glucose after a 75-g oral glucose tolerance test, and HbA1c were measured at baseline and follow-up.RESULTS:
During the follow-up period, 825 participants were diagnosed with T2DM. In multivariable Cox regression analyses, after adjusting for covariates, a strong positive association between BMI and incident T2DM was found in the whole population; however, when stratified by age groups (20-39, 40-59, and 60-74 years), the risk associations between BMI and incident T2DM decreased with increasing age and were no longer evident in the 60-74 years group (Pinteraction < 0.001). The optimal BMI cut-off points for predicting T2DM risk for men and women were 25.5 and 24.4 kg/m2 , respectively, in the 20-39 years group, and 23.5 and 23.0 kg/m2 , respectively, in the 40-59 years group. There was no predictive performance of BMI in the 60-74 years group for either sex.CONCLUSIONS:
The results suggest that the performance of BMI in predicting T2DM risk was best in subjects of younger age and decreased with age. Age- and sex-specific BMI cut-off points should be considered for T2DM risk stratification in the Chinese population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Massa Corporal
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Diabetes Mellitus Tipo 2
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Circunferência da Cintura
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article