Increased risk of respiratory diseases in adults with Type 1 and Type 2 diabetes.
Diabetes Res Clin Pract
; 142: 46-55, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29802957
ABSTRACT
AIMS:
Diabetes is linked with decreases in lung elasticity and in capacity to transfer carbon monoxide. Systemic inflammation, a common concern with diabetes, may contribute to airflow obstruction. We examined the association of self-reported diabetes with self-reported respiratory diseases (RDs) among 53,146 adults from the C8 Health Project.METHODS:
Participants were categorized into three groups Type 1 (T1D, nâ¯=â¯781), Type 2 (T2D, nâ¯=â¯4277), or no diabetes (nâ¯=â¯48,088). ORs (95% CIs) for the association of diabetes with four RDs were computed emphysema, chronic obstructive pulmonary disease (COPD), chronic bronchitis (CB), and asthma. Covariates controlled for were age, sex, estimated glomerular filtration rate, C-reactive protein, smoking history, BMI, and perfluorooctonaoic acid (C8).RESULTS:
RDs were present in 26%, 21% and 13% of persons with T1D, T2D, and no diabetes, respectively. In multivariable analyses, persons with T1D were 62% more likely to have any RD (OR 1.62, CI (1.36-1.93)), while those with T2D were 1.3 times as likely (OR 1.26, CI 1.15-1.37)). Compared to those without diabetes, in those with T1D and T2D diabetes respectively, ORs (CIs) for COPD were 1.89 (1.38-2.57), 1.45 (1.23-1.71), asthma 1.51 (1.21-1.87), 1.38 (1.24-1.53), CB 1.96 (1.57-2.45), 1.35 (1.20-1.52) and emphysema 1.25 (0.85-1.82), 1.31 (1.10-1.56). Population attributable risks for any RDs associated with a history of smoking were 19%, 30%, and 26% for those with Type 1, Type 2, and no diabetes respectively.CONCLUSIONS:
Diabetes, more so in T1D, appears to increase RD risk. Smoking is an important risk factor, but not as informative in Type 1 diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Bronquite Crônica
/
Doença Pulmonar Obstrutiva Crônica
/
Diabetes Mellitus Tipo 2
/
Pulmão
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article