A blueprint for human whole-cell modeling.
Curr Opin Syst Biol
; 7: 8-15, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29806041
ABSTRACT
Whole-cell dynamical models of human cells are a central goal of systems biology. Such models could help researchers understand cell biology and help physicians treat disease. Despite significant challenges, we believe that human whole-cell models are rapidly becoming feasible. To develop a plan for achieving human whole-cell models, we analyzed the existing models of individual cellular pathways, surveyed the biomodeling community, and reflected on our experience developing whole-cell models of bacteria. Based on these analyses, we propose a plan for a project, termed the Human Whole-Cell Modeling Project, to achieve human whole-cell models. The foundations of the plan include technology development, standards development, and interdisciplinary collaboration.
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MEDLINE
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En
Ano de publicação:
2018
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Article