Down-regulation of CD19 expression inhibits proliferation, adhesion, migration and invasion and promotes apoptosis and the efficacy of chemotherapeutic agents and imatinib in SUP-B15 cells.

Wu, Junqing; Liang, Bin; Qian, Yan; Tang, Liyuan; Xing, Chongyun; Zhuang, Qiang; Shen, Zhijian; Jiang, Songfu; Yu, Kang; Feng, Jianhua

Wu, Junqing; Liang, Bin; Qian, Yan; Tang, Liyuan; Xing, Chongyun; Zhuang, Qiang; Shen, Zhijian; Jiang, Songfu; Yu, Kang; Feng, Jianhua.

Afiliação

Wu J; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Liang B; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Qian Y; Division of Pediatric Hematology-Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Tang L; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Xing C; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Zhuang Q; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Shen Z; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Jiang S; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Yu K; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.
Feng J; Division of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, PR China.

Cell Biol Int ; 42(9): 1228-1239, 2018 Sep.

Article em En | MEDLINE | ID: mdl-29809305

Assuntos

Antígenos CD19/genética; Antígenos CD19/metabolismo; Leucemia Mielogênica Crônica BCR-ABL Positiva/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Apoptose/efeitos dos fármacos; Adesão Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Criança; Regulação para Baixo/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Humanos; Mesilato de Imatinib/metabolismo; Mesilato de Imatinib/farmacologia; Leucemia Mielogênica Crônica BCR-ABL Positiva/genética; Invasividade Neoplásica/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

CD19; SUP-B15 cells; cell apoptosis; cell motility; drug sensitivity; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mielogênica Crônica BCR-ABL Positiva / Antígenos CD19 Limite: Child / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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