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Effect of Heart Rate-Oriented Therapy on Diastolic Functions in Patients with Heart Failure with Reduced Ejection Fraction.
Tas, Sedat; Tas, Ümmü; Özpelit, Ebru; Edem, Efe; Akdeniz, Bahri.
Afiliação
  • Tas S; Cardiology Department, Celal Bayar University Faculty of Medicine Hospital.
  • Tas Ü; Cardiology Department, Akhisar State Hospital.
  • Özpelit E; Cardiology Department, Dokuz Eylül University Faculty of Medicine Hospital.
  • Edem E; Cardiology Department, Izmir Tinaztepe Hospital, Turkey.
  • Akdeniz B; Cardiology Department, Dokuz Eylül University Faculty of Medicine Hospital.
Acta Cardiol Sin ; 34(3): 251-258, 2018 May.
Article em En | MEDLINE | ID: mdl-29844646
ABSTRACT

BACKGROUND:

Resting heart rate (HR) is a strong predictor of cardiovascular mortality and morbidity in patients with heart failure with reduced ejection fraction (HFrEF). However, the effects of HR-lowering therapy on diastolic function in HFrEF patients are not well described. In this study, we aimed to investigate the effect of lowering HR on diastolic function in HFrEF patients with sinus rhythm.

METHODS:

Fifty patients with HFrEF with coexisting diastolic dysfunction and sinus rhythm with resting HR > 70 bpm were prospectively included in the study. All patients were treated with intended HR-lowering therapy, which targeted a HR below 70 bpm. We divided the whole population according to the resting HR achieved with strict rate control (group 1) and to that achieved without strict rate control (group 2; HR > 70 bpm) at the end of the study. Left ventricular diastolic function and B-type natriuretic peptide (BNP) values at baseline and at the end of the study were compared in both groups.

RESULTS:

No significant differences were found between the groups in terms of baseline parameters except for lower diastolic blood pressure in group 2. At the end of follow-up, E/Em ratio, E/A ratio and left atrial area significantly decreased with an increased deceleration time in group 1. The changes in HR (delta HR) were correlated with E/Em (r = 0.67, p < 0.001) and delta BNP level (r = 0.49, p < 0.001).

CONCLUSIONS:

No significant differences were found between the groups in terms of baseline parameters except for lower diastolic blood pressure in group 2. At the end of follow-up, E/Em ratio, E/A ratio and left atrial area significantly decreased with an increased deceleration time in group 1. The changes in HR (delta HR) were correlated with E/Em (r = 0.67, p < 0.001) and delta BNP level (r = 0.49, p < 0.001).
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article