Expression Profiling Analysis Reveals Key MicroRNA-mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa.
Invest Ophthalmol Vis Sci
; 59(6): 2381-2392, 2018 05 01.
Article
em En
| MEDLINE
| ID: mdl-29847644
ABSTRACT
Purpose:
The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the disease.Methods:
miRNAs-mRNA interaction networks were generated for analysis of biological pathways involved in retinal degeneration.Results:
Of more than 1900 miRNAs analyzed, we selected 19 miRNAs on the basis of (1) a significant differential expression in rd10 retinas compared with control samples and (2) an inverse expression relationship with predicted mRNA targets involved in biological pathways relevant to retinal biology and/or degeneration. Seven of the selected miRNAs have been associated with retinal dystrophies, whereas, to our knowledge, nine have not been previously linked to any disease.Conclusions:
This study contributes to our understanding of the etiology and progression of retinal degeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Degeneração Retiniana
/
RNA Mensageiro
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Retinose Pigmentar
/
Regulação da Expressão Gênica
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Células Fotorreceptoras Retinianas Bastonetes
/
MicroRNAs
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article