Immune-inhibitive phenyl-C1 substituent aporphine alkaloids from Thalictrum cirrhosum.
Fitoterapia
; 128: 247-252, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29852264
ABSTRACT
Five new phenyl-C1 substituent aporphine alkaloids, 6aR-2'-methoxycarbonyl-thaliadin (1), 6aR-2'-carboxyl-thaliadin (2), 6aR-3-methoxy-hernandalinol (3), 6aS-1,3,10-trimethoxy-natalamine (4), and 3-methoxy-2'-methoxycarbonyl-oxohernandalincin (5), together with sixteen known isoquinoline alkaloids (6-21) were isolated from the whole herb of Thalictrum cirrhosum (Levl.). Their structures were elucidated by extensive spectroscopic measurements, and six isoquinoline alkaloids showed significant inhibitory activity on concanavalin A-stimulated splenocytes proliferation with IC50 values 36-44⯵M by the immunosuppressive bioassay.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aporfinas
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Thalictrum
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Alcaloides
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Isoquinolinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article