PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.
BMC Cancer
; 18(1): 612, 2018 May 31.
Article
em En
| MEDLINE
| ID: mdl-29855276
ABSTRACT
BACKGROUND:
Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.METHODS:
To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry.RESULTS:
PSCA staining was absent in normal epithelial and stromal cells of the prostate. Membranous and cytoplasmic PSCA staining was seen in 53.7% of 9642 interpretable tumors. Staining was weak in 22.4%, moderate in 24.5% and strong in 6.8% of tumors. PSCA expression was associated with favorable pathological and clinical tumor features Early pathological tumor stage (p < 0.0001), low Gleason grade (p < 0.0001), absence of lymph node metastasis (p < 0.0001), low pre-operative PSA level (p = 0.0118), negative surgical margin (p < 0.0001) and reduced PSA recurrence (p < 0.0001). PSCA expression was an independent predictor of prognosis in multivariate analysis (hazard ratio 0.84, p < 0.0001).CONCLUSIONS:
The absence of statistical relationship to TMPRSS2ERG fusion status, chromosomal deletion or high tumor cell proliferation argues against a major role of PSCA for regulation of cell cycle or genomic integrity. PSCA expression is linked to favorable prognosis. PSCA measurement is a candidate for inclusion in multi-parametric prognostic prostate cancer tests.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Calicreínas
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Antígeno Prostático Específico
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Antígenos de Neoplasias
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Proteínas de Neoplasias
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Recidiva Local de Neoplasia
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article