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Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity.
Reilly, Sean W; Puentes, Laura N; Wilson, Khadija; Hsieh, Chia-Ju; Weng, Chi-Chang; Makvandi, Mehran; Mach, Robert H.
Afiliação
  • Reilly SW; Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Puentes LN; Department of Systems Pharmacology and Translational Therapeutics , University of Pennsylvania , 421 Curie Blvd. , Philadelphia , Pennsylvania 19104 , United States.
  • Wilson K; Department of Systems Pharmacology and Translational Therapeutics , University of Pennsylvania , 421 Curie Blvd. , Philadelphia , Pennsylvania 19104 , United States.
  • Hsieh CJ; Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Weng CC; Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Makvandi M; Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
  • Mach RH; Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
J Med Chem ; 61(12): 5367-5379, 2018 06 28.
Article em En | MEDLINE | ID: mdl-29856625
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Piperazinas / Dano ao DNA / Inibidores de Poli(ADP-Ribose) Polimerases / Piperazina Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ftalazinas / Piperazinas / Dano ao DNA / Inibidores de Poli(ADP-Ribose) Polimerases / Piperazina Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article