[Lignanoids from an aqueous extract of the roots of Codonopsis pilosula].
Yao Xue Xue Bao
; 51(4): 616-25, 2016 04.
Article
em Zh
| MEDLINE
| ID: mdl-29860746
ABSTRACT
Sixteen lignanoids were isolated from an aqueous extract of the commonly used Chinese traditional medicine Dangshen, the dried roots of Codonopsis pilosula, by using a combination of various chromatographic techniques, including silica gel, macroporous adsorbent resin, MCI resin, sephadex LH-20, and reversed phase semi-preparative HPLC. On the basis of spectral data analysis, their structures were elucidated and identified asï¼-ï¼-ï¼7R,7'R,8R,8'Sï¼-4,4'-dihydroxy-3,3',5,5',7-pentamethoxy-2,7'-cyclolignaneï¼1ï¼,ï¼-ï¼-ï¼7R,8Sï¼- dihydrodehydrodiconiferyl alcohol 4-O-ß-D-glucopyranosyl-ï¼1'''â2''ï¼-ß-D-glucopyranosideï¼2ï¼,ï¼-ï¼-ï¼7R,8Sï¼- dihydrodehydrodiconiferyl alcoholï¼3ï¼,ï¼+ï¼-ï¼7S,8Rï¼-dehydrodiconiferyl alcoholï¼4ï¼,ï¼+ï¼-balanophoninï¼5ï¼,ï¼+ï¼- demethoxypinoresinolï¼6ï¼,ï¼+ï¼-pinoresinolï¼7ï¼,ï¼+ï¼-epipinoresinolï¼8ï¼,ï¼-ï¼-syringaresinolï¼9ï¼,ï¼-ï¼-medioresinolï¼10ï¼,ï¼-ï¼-lariciresinolï¼11ï¼,ï¼-ï¼-secoisolariciresinolï¼12ï¼,ï¼-ï¼-ent-isolariciresinolï¼13ï¼,ï¼+ï¼-ï¼7S,8Sï¼-3-methoxy-3',7- expoxy-8,4'-neolignan-4,9,9'-triolï¼14ï¼,ï¼+ï¼-ï¼7S,8Rï¼-3',4-dihydroxy-3-methoxy-8,4'-neolignanï¼15ï¼, andï¼-ï¼-ï¼7R,8Rï¼-3',4-dihydroxy-3-methoxy-8,4'-neolignanï¼16ï¼. All these compounds were isolated from C. pilosula for the first time, while compound 1 is a new natural product of 2,7'-cyclolignan and 2 is a new 4',7-epoxy- 8,3'-neolignan diglucoside. Compound 12 showed activity against Fe(2+)-cysteine induced rat liver microsomal lipid peroxidation with an inhibition ratio ofï¼63.4 ± 8.3ï¼ % at 1×10(-5) mol·L(-1).
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Raízes de Plantas
/
Codonopsis
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article