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Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum.
Ganna, Andrea; Satterstrom, F Kyle; Zekavat, Seyedeh M; Das, Indraniel; Kurki, Mitja I; Churchhouse, Claire; Alfoldi, Jessica; Martin, Alicia R; Havulinna, Aki S; Byrnes, Andrea; Thompson, Wesley K; Nielsen, Philip R; Karczewski, Konrad J; Saarentaus, Elmo; Rivas, Manuel A; Gupta, Namrata; Pietiläinen, Olli; Emdin, Connor A; Lescai, Francesco; Bybjerg-Grauholm, Jonas; Flannick, Jason; Mercader, Josep M; Udler, Miriam; Laakso, Markku; Salomaa, Veikko; Hultman, Christina; Ripatti, Samuli; Hämäläinen, Eija; Moilanen, Jukka S; Körkkö, Jarmo; Kuismin, Outi; Nordentoft, Merete; Hougaard, David M; Mors, Ole; Werge, Thomas; Mortensen, Preben Bo; MacArthur, Daniel; Daly, Mark J; Sullivan, Patrick F; Locke, Adam E; Palotie, Aarno; Børglum, Anders D; Kathiresan, Sekar; Neale, Benjamin M.
Afiliação
  • Ganna A; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Satterstrom FK; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Zekavat SM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Genomic Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Das I; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Kurki MI; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Molecular Medicine Finland, FIMM, University of Helsin
  • Churchhouse C; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Alfoldi J; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Martin AR; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Havulinna AS; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00290, Finland; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Byrnes A; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Thompson WK; Department of Psychiatry, University of California, San Diego, CA 94143, USA; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde 4000, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; KG Jebsen Centre for P
  • Nielsen PR; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus 8210, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus 8210, Denma
  • Karczewski KJ; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Saarentaus E; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00290, Finland.
  • Rivas MA; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA.
  • Gupta N; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Pietiläinen O; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, University of Harvard, Cambridge, MA 02138, USA.
  • Emdin CA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lescai F; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus 8210, Denmark; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus 8210, Denmark.
  • Bybjerg-Grauholm J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen 2300, Denmark.
  • Flannick J; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Genomic Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Mercader JM; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Udler M; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70211, Finland.
  • Salomaa V; Department of Health, THL-National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Hultman C; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17176, Sweden.
  • Ripatti S; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00290, Finland; Department of Public Health, University of Helsinki, Helsinki 00014, Finland; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Hämäläinen E; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00290, Finland.
  • Moilanen JS; Department of Clinical Genetics, Oulu University Hospital, Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu 90029, Finland.
  • Körkkö J; Department of Clinical Genetics, Oulu University Hospital, Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu 90029, Finland.
  • Kuismin O; Department of Clinical Genetics, Oulu University Hospital, Medical Research Center Oulu and PEDEGO Research Unit, University of Oulu, Oulu 90029, Finland.
  • Nordentoft M; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen 2100, Denmark.
  • Hougaard DM; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen 2300, Denmark.
  • Mors O; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Psychosis Research Unit, Aarhus University Hospital, Risskov 8240, Denmark.
  • Werge T; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde 4000, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen 2200, Denmark.
  • Mortensen PB; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; National Centre for Register-based Research, School of Business and Social Sciences, Aarhus University, Aarhus 8210, Denmark; Centre for Integrated Register-based Research, Aarhus University, Aarhus 8210, Denma
  • MacArthur D; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Daly MJ; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17176, Sweden; Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
  • Palotie A; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
  • Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark; iSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus 8210, Denmark; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus 8210, Denmark.
  • Kathiresan S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Genomic Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Neale BM; Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and
Am J Hum Genet ; 102(6): 1204-1211, 2018 06 07.
Article em En | MEDLINE | ID: mdl-29861106
ABSTRACT
There is a limited understanding about the impact of rare protein-truncating variants across multiple phenotypes. We explore the impact of this class of variants on 13 quantitative traits and 10 diseases using whole-exome sequencing data from 100,296 individuals. Protein-truncating variants in genes intolerant to this class of mutations increased risk of autism, schizophrenia, bipolar disorder, intellectual disability, and ADHD. In individuals without these disorders, there was an association with shorter height, lower education, increased hospitalization, and reduced age at enrollment. Gene sets implicated from GWASs did not show a significant protein-truncating variants burden beyond what was captured by established Mendelian genes. In conclusion, we provide a thorough investigation of the impact of rare deleterious coding variants on complex traits, suggesting widespread pleiotropic risk.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fases de Leitura Aberta / Mutação Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fases de Leitura Aberta / Mutação Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article