Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis.

Li, Tian-Neng; Wu, Yi-Ju; Tsai, Hung-Wen; Sun, Cheng-Pu; Wu, Yi-Hsuan; Wu, Hui-Lin; Pei, Yi-Ning; Lu, Kuan-Ying; Yen, Tim Ting-Chung; Chang, Chien-Wen; Chan, Hong-Lin; Tao, Mi-Hua; Liou, Jun-Yang; Chang, Margaret Dah-Tsyr; Su, Ih-Jen; Wang, Lily Hui-Ching

Li, Tian-Neng; Wu, Yi-Ju; Tsai, Hung-Wen; Sun, Cheng-Pu; Wu, Yi-Hsuan; Wu, Hui-Lin; Pei, Yi-Ning; Lu, Kuan-Ying; Yen, Tim Ting-Chung; Chang, Chien-Wen; Chan, Hong-Lin; Tao, Mi-Hua; Liou, Jun-Yang; Chang, Margaret Dah-Tsyr; Su, Ih-Jen; Wang, Lily Hui-Ching.

Afiliação

Li TN; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Wu YJ; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Tsai HW; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.
Sun CP; Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.
Wu YH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wu HL; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Pei YN; Hepatitis Research Centre, National Taiwan University Hospital, Taipei, Taiwan.
Lu KY; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Yen TT; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chang CW; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chan HL; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Tao MH; Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.
Liou JY; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.
Chang MD; Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan.
Su IJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Wang LH; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan.

J Pathol ; 245(4): 502-513, 2018 08.

Article em En | MEDLINE | ID: mdl-29862509

Assuntos

Carcinoma Hepatocelular/virologia; Citocinese; Antígenos de Superfície da Hepatite B/metabolismo; Vírus da Hepatite B/metabolismo; Hepatite B Crônica/virologia; Hepatócitos/virologia; Neoplasias Hepáticas/virologia; Ploidias; Animais; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Proteínas de Ciclo Celular/metabolismo; Transformação Celular Viral; Dano ao DNA; Modelos Animais de Doenças; Pontos de Checagem da Fase G2 do Ciclo Celular; Células Hep G2; Antígenos de Superfície da Hepatite B/genética; Vírus da Hepatite B da Marmota/genética; Vírus da Hepatite B da Marmota/metabolismo; Vírus da Hepatite B/genética; Hepatite B Crônica/genética; Hepatite B Crônica/metabolismo; Hepatite B Crônica/patologia; Hepatócitos/metabolismo; Hepatócitos/patologia; Hepatócitos/transplante; Interações Hospedeiro-Patógeno; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Marmota; Camundongos Transgênicos; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Proto-Oncogênicas/metabolismo; Quinase 1 Polo-Like

Palavras-chave

G2/M checkpoint; LHBS; ground-glass hepatocytes; polo-like kinase-1; polyploidy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ploidias / Vírus da Hepatite B / Carcinoma Hepatocelular / Hepatite B Crônica / Hepatócitos / Citocinese / Antígenos de Superfície da Hepatite B / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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