Phase-Variable Genotypes Sweetened by Glycosylation Phenotypes.
J Bacteriol
; 200(16)2018 08 15.
Article
em En
| MEDLINE
| ID: mdl-29866804
ABSTRACT
The affordability of bacterial genome sequencing has provided a helpful tool for sequencing large strain collections. Bente Børud (J. Bacteriol. 200e00794-17, 2018, https//doi.org/doi10.1128/JB.00794-17) recently led an effort to analyze the genomes of a collection of oropharyngeal Neisseria meningitidis isolates from 50 healthy individuals. Paired longitudinal isolates from each individual were sequenced. Genome analyses focused on (i) predicting the expression state of phase-variable loci that encode enzymes important for O-linked protein glycosylation and (ii) correlating specific genotypes with glycosylation phenotypes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Meningocócicas
/
Neisseria meningitidis
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article