Calcium signalling and related ion channels in neutrophil recruitment and function.
Eur J Clin Invest
; 48 Suppl 2: e12964, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29873837
ABSTRACT
The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca2+ store depletion and the influx of extracellular Ca2+ via ion channels, play a critical role in synchronizing neutrophil activation and function. In this review, we provide an overview of how Ca2+ signalling is initiated in neutrophils and how changes in intracellular Ca2+ levels modulate neutrophil function.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinalização do Cálcio
/
Infiltração de Neutrófilos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article