From CO2 to 4 H-Quinolizin-4-ones: A One-Pot Multicomponent Approach via Ag2O/Cs2CO3 Orthogonal Tandem Catalysis.
J Org Chem
; 83(16): 9561-9567, 2018 08 17.
Article
em En
| MEDLINE
| ID: mdl-29874460
ABSTRACT
Using carbon dioxide as a C1 precursor, here we report relatively simple and cost-effective orthogonal tandem catalysis, namely Ag2O in conjunction with Cs2CO3 serves to promote a multicomponent tandem reaction forming two new C-C and one new C-N bonds. 4 H-Quinolizin-4-ones, key skeletal components in a variety of biologically active molecules, were obtained with yields up to 99%. The present approach features a broad substrate scope and mild reaction conditions and benefits from using cost-effective reaction and catalysts.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article