Linking PRMT5 to breast cancer stem cells: New therapeutic opportunities?

Chiang, Kelly; Davies, Clare C

Chiang, Kelly; Davies, Clare C.

Afiliação

Chiang K; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, UK.
Davies CC; Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, UK.

Mol Cell Oncol ; 5(3): e1441628, 2018.

Article em En | MEDLINE | ID: mdl-29876520

ABSTRACT

ABSTRACT

The arginine methyltransferase PRMT5 has been increasingly associated with cancer development. Here we describe our recent findings that PRMT5 is a critical regulator of breast cancer stem cell survival via the epigenetic regulation of FOXP1. Consequently, PRMT5 inhibitors could potentially eradicate cancer stem cells thereby preventing tumour relapse.

Palavras-chave

FOXP1; PRMT5; arginine methylation; breast cancer stem cells; epigenetics

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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