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Host Resistance Assays.
Burleson, Stefanie C M; Freebern, Wendy Jo; Burleson, Florence G; Burleson, Gary R; Johnson, Victor J; Luebke, Robert W.
Afiliação
  • Burleson SCM; Burleson Research Technologies, Inc. (BRT), Morrisville, NC, USA.
  • Freebern WJ; Bristol-Myers Squibb Company, Immunotoxicology, New Brunswick, NJ, USA.
  • Burleson FG; Burleson Research Technologies, Inc. (BRT), Morrisville, NC, USA.
  • Burleson GR; Burleson Research Technologies, Inc. (BRT), Morrisville, NC, USA.
  • Johnson VJ; Burleson Research Technologies, Inc. (BRT), Morrisville, NC, USA.
  • Luebke RW; United States Environmental Protection Agency, Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, National Health and Environmental Effects Laboratory, Office of Research and Development, Research Triangle Park, NC, USA.
Methods Mol Biol ; 1803: 117-145, 2018.
Article em En | MEDLINE | ID: mdl-29882137
ABSTRACT
The goal of immunotoxicity testing is to obtain data useful for immunotoxicity safety assessment. Guidance in the performance of immunotoxicity safety evaluations is provided in documents from the US EPA for chemicals and the ICH S8 document for pharmaceuticals. The ICH S8 document outlines a tiered approach that includes (1) standard toxicity studies with associated hematology, immune system organ weights, and histopathology data; (2) functional assays, such as cytotoxic T lymphocyte (CTL) assays, natural killer (NK) cell assays, respiratory burst, phagocytosis, and T-cell-dependent antibody response (TDAR) assays; and (3) host resistance assays. Host resistance assays are considered the gold standard in immunotoxicity testing and provide a critical overview of the extent to which innate, adaptive, and homeostatic regulatory immune functions are integrated to protect the host. Both comprehensive and targeted host resistance assays are available, each with distinct advantages. This chapter serves to provide a general overview of the various assays that may be used, as well as a summary of procedures.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bioensaio / Testes de Toxicidade / Resistência à Doença Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bioensaio / Testes de Toxicidade / Resistência à Doença Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article