Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin.

Wei, Yangjie; Xiong, Jian; Larson, Nicholas R; Iyer, Vidyashankara; Sanyal, Gautam; Joshi, Sangeeta B; Volkin, David B; Middaugh, C Russell

Wei, Yangjie; Xiong, Jian; Larson, Nicholas R; Iyer, Vidyashankara; Sanyal, Gautam; Joshi, Sangeeta B; Volkin, David B; Middaugh, C Russell.

Afiliação

Wei Y; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047.
Xiong J; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047.
Larson NR; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047.
Iyer V; Biopharmaceutical Development, Medimmune Inc., Gaithersburg, Maryland 20878.
Sanyal G; Biopharmaceutical Development, Medimmune Inc., Gaithersburg, Maryland 20878.
Joshi SB; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047.
Volkin DB; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047.
Middaugh CR; Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047. Electronic address: middaugh@ku.edu.

J Pharm Sci ; 107(9): 2325-2334, 2018 09.

Article em En | MEDLINE | ID: mdl-29883666

Assuntos

Adjuvantes Imunológicos/química; Toxinas Bacterianas/química; Emulsões/química; Proteínas Hemolisinas/química; Temperatura Alta; Adjuvantes Imunológicos/análise; Adjuvantes Farmacêuticos/análise; Adjuvantes Farmacêuticos/química; Toxinas Bacterianas/análise; Emulsões/análise; Proteínas Hemolisinas/análise; Temperatura Alta/efeitos adversos; Estabilidade Proteica; Espectroscopia de Infravermelho com Transformada de Fourier/métodos; Staphylococcus aureus

Palavras-chave

Staphylococcus aureus alpha-toxin; emulsion adjuvant; protein structure; squalene; stability; vaccine formulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Adjuvantes Imunológicos / Emulsões / Temperatura Alta / Proteínas Hemolisinas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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