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Toward Precision Medicine for Neurological and Neuropsychiatric Disorders.
Gibbs, Rebecca M; Lipnick, Scott; Bateman, Joel W; Chen, Lloyd; Cousins, Henry C; Hubbard, Elizabeth G; Jowett, Geraldine; LaPointe, Darren S; McGredy, Maxine J; Odonkor, Michelle N; Repetti, Giuliana; Thomas, Elizabeth; Rubin, Lee L.
Afiliação
  • Gibbs RM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Lipnick S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
  • Bateman JW; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Chen L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Cousins HC; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Hubbard EG; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Jowett G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • LaPointe DS; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • McGredy MJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Odonkor MN; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Repetti G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
  • Thomas E; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  • Rubin LL; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: lee_rubin@harvard.edu.
Cell Stem Cell ; 23(1): 21-24, 2018 07 05.
Article em En | MEDLINE | ID: mdl-29887317
ABSTRACT
The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Transplante de Células-Tronco / Medicina de Precisão / Transtornos Mentais / Doenças do Sistema Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Transplante de Células-Tronco / Medicina de Precisão / Transtornos Mentais / Doenças do Sistema Nervoso Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article