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Argon plasma coagulation of actinic keratoses imaged by optical coherence tomography: An in vivo study indicating a possible lesion-directed treatment.
Schmitz, Lutz; Hessam, Schapoor; Scholl, Lisa; Reitenbach, Sarah; Segert, Marc H; Gambichler, Thilo; Stockfleth, Eggert; Bechara, Falk G.
Afiliação
  • Schmitz L; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
  • Hessam S; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
  • Scholl L; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
  • Reitenbach S; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
  • Segert MH; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
  • Gambichler T; Department of Dermatology, Skin Cancer Centre, Ruhr-University Bochum, Bochum, Germany.
  • Stockfleth E; Department of Dermatology, Skin Cancer Centre, Ruhr-University Bochum, Bochum, Germany.
  • Bechara FG; Department of Dermatology, Surgery Unit, Ruhr-University Bochum, Bochum, Germany.
J Biophotonics ; 11(10): e201800075, 2018 10.
Article em En | MEDLINE | ID: mdl-29893051
ABSTRACT
Actinic keratoses (AKs) can progress into invasive squamous cell carcinoma and thus may become a life threatening disease. Argon plasma coagulation (APC) might complement the therapeutic armamentarium in particular for AK lesions. However, there is no data on APC-induced micromorphological changes following the treatment of AKs. We aimed to determine in vivo APC-induced effects on the epidermis and dermoepidermal junction (DEJ) zone in AK lesions. We performed APC in 108 AKs using the spray mode with a power setting of 15 W and a flow rate of 2.0 L/min. Before and after the intervention, optical coherence tomography (OCT) was performed. After APC, 74.2% (46/62) lesions presented with clearly demarcated DEJ and without any epidermal tissue left, 25.8% (16/62) of treated lesions showed residual epidermal tissue left. In 19.4% (12/62), parts of the DEJ and in 6.5% (4/62), the entire DEJ could not be discriminated. The χ2 test showed a significant (P = 0.0025) association between the presence of hyperkeratosis prior to APC and intact DEJ after APC. In conclusion, APC as shown by OCT is a well controllable treatment modality for AKs causing only limited damage to dermal tissue. Further studies are needed to evaluate clinical outcome as well as recurrence rates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia de Coerência Óptica / Ceratose Actínica / Coagulação com Plasma de Argônio Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tomografia de Coerência Óptica / Ceratose Actínica / Coagulação com Plasma de Argônio Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article