Vaccine potential of ESAT-6 protein fused with consensus CD4<sup>+</sup> T-cell epitopes of PE/PPE proteins against highly pathogenic Mycobacterium tuberculosis strain HN878.

Choi, Soo-Young; Kwon, Kee Woong; Kim, Hongmin; Choi, Hong-Hee; Shin, Sung Jae

Vaccine potential of ESAT-6 protein fused with consensus CD4⁺ T-cell epitopes of PE/PPE proteins against highly pathogenic Mycobacterium tuberculosis strain HN878.

Choi, Soo-Young; Kwon, Kee Woong; Kim, Hongmin; Choi, Hong-Hee; Shin, Sung Jae.

Afiliação

Choi SY; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Kwon KW; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Kim H; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Choi HH; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Shin SJ; Department of Microbiology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, South Korea. Electronic address: sjshin@yuhs.ac.

Biochem Biophys Res Commun ; 503(4): 2195-2201, 2018 09 18.

Article em En | MEDLINE | ID: mdl-29894686

Assuntos

Antígenos de Bactérias/imunologia; Proteínas de Bactérias/imunologia; Epitopos de Linfócito T/imunologia; Mycobacterium tuberculosis/imunologia; Vacinas de Subunidades Antigênicas/síntese química; Sequência de Aminoácidos; Animais; Antígenos de Bactérias/genética; Antígenos de Bactérias/uso terapêutico; Proteínas de Bactérias/genética; Proteínas de Bactérias/uso terapêutico; Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Epitopos de Linfócito T/genética; Epitopos de Linfócito T/uso terapêutico; Interferon gama/efeitos dos fármacos; Interferon gama/metabolismo; Interleucina-2/metabolismo; Camundongos; Mycobacterium tuberculosis/efeitos dos fármacos; Engenharia de Proteínas; Proteínas Recombinantes de Fusão/imunologia; Proteínas Recombinantes de Fusão/farmacologia; Vacinas de Subunidades Antigênicas/farmacologia

Palavras-chave

ESAT-6; Mycobacterium tuberculosis; PE/PPE; Tuberculosis; Vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Epitopos de Linfócito T / Vacinas de Subunidades Antigênicas / Mycobacterium tuberculosis / Antígenos de Bactérias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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