Three-year renal function trajectory and its association with adverse renal event in patients with type 2 diabetes.
J Diabetes Complications
; 32(8): 784-790, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29895439
ABSTRACT
AIMS:
The study evaluated associations between 3-year eGFR trajectory patterns and adverse renal event in diabetic patients.METHODS:
Adverse renal event was defined as sustained eGFR <60 or one ACR >300â¯mg/g creatinine. Cox proportional hazards models evaluated association between eGFR trajectory patterns and adverse renal event.RESULTS:
We detected six clusters. Cluster 1 had a stable but relatively low baseline eGFR level (nâ¯=â¯823, 20.52%), cluster 2 had a high baseline eGFR level, but slightly decreased afterwards (nâ¯=â¯1708, 42.59%), cluster 3 had an increasing eGFR during the first 15-month follow-up and then a decline rate (nâ¯=â¯505, 12.59%), cluster 4 decreased during the first 9-month follow-up and then remained stable (nâ¯=â¯774, 19.30%), cluster 5 had a sharp decline and then was elevated after 21â¯months until the end of follow-up (nâ¯=â¯135, 3.37%), and cluster 6 had an extremely fluctuating eGFR and then a sharp increase at the last 12-month period (nâ¯=â¯65, 1.62%). Clusters 1, 3, and 4 show increased adverse renal risks compared with cluster 2 (2.24, 1.69-2.97; 2.70, 2.02-3.61; and 2.15, 1.64-2.83, respectively).CONCLUSIONS:
Patients with sustained low-level renal function, renal decline, or increasing trend in eGFR trajectory encountered an increased CKD risk.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
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Rim
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article