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Model-based identification of TNFα-induced IKKß-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt, Angela; Kaschek, Daniel; Huppelschoten, Suzanna; Sison-Young, Rowena; Zhang, Fang; Buck-Wiese, Marie; Herrmann, Franziska; Malkusch, Sebastian; Krüger, Carmen L; Meub, Mara; Merkt, Benjamin; Zimmermann, Lea; Schofield, Amy; Jones, Robert P; Malik, Hassan; Schilling, Marcel; Heilemann, Mike; van de Water, Bob; Goldring, Christopher E; Park, B Kevin; Timmer, Jens; Klingmüller, Ursula.
Afiliação
  • Oppelt A; 1Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Kaschek D; 2Institute of Physics, University of Freiburg, Freiburg, Germany.
  • Huppelschoten S; 3Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Sison-Young R; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Zhang F; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Buck-Wiese M; 1Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Herrmann F; 1Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Malkusch S; 5Institute of Physical and Theoretical Chemistry, Single Molecule Biophysics, Johann Wolfgang Goethe-University, Frankfurt, Germany.
  • Krüger CL; 5Institute of Physical and Theoretical Chemistry, Single Molecule Biophysics, Johann Wolfgang Goethe-University, Frankfurt, Germany.
  • Meub M; 5Institute of Physical and Theoretical Chemistry, Single Molecule Biophysics, Johann Wolfgang Goethe-University, Frankfurt, Germany.
  • Merkt B; 2Institute of Physics, University of Freiburg, Freiburg, Germany.
  • Zimmermann L; 1Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Schofield A; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Jones RP; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Malik H; 6North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Liverpool, UK.
  • Schilling M; 6North Western Hepatobiliary Unit, Aintree University Hospital NHS Foundation Trust, Liverpool, UK.
  • Heilemann M; 1Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • van de Water B; 5Institute of Physical and Theoretical Chemistry, Single Molecule Biophysics, Johann Wolfgang Goethe-University, Frankfurt, Germany.
  • Goldring CE; 7Bioquant, University of Heidelberg, Heidelberg, Germany.
  • Park BK; 3Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Timmer J; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
  • Klingmüller U; 4MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
NPJ Syst Biol Appl ; 4: 23, 2018.
Article em En | MEDLINE | ID: mdl-29900006
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article