Circulating miRNA-302 family members as potential biomarkers for the diagnosis of acute heart failure.
Biomark Med
; 12(8): 871-880, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29900754
ABSTRACT
AIM:
To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis.METHODS:
Three groups of subjects, in other words, AHF patients, AHF free patients and healthy controls were recruited. Circulating levels of miR-302 family members were measured and analyzed for AHF diagnosis.RESULTS:
Plasma miR-302s except miR-302f were significantly elevated in AHF patients. MiR-302b-3p had the highest area under curve value of 0.87. There were strong positive correlations between miR-302s and NT-proBNP levels. MiR-302b-3p levels were significantly higher in left ventricular ejection fraction ≤45% and New York Heart Association class IV patients compared with left ventricular ejection fraction >45% and New York Heart Association class II patients, respectively.CONCLUSION:
Levels of circulating miR-302s, miR-302b-3p in particular, could be potentially applied for AHF diagnosis and the differentiation of disease severity.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Volume Sistólico
/
MicroRNAs
/
Insuficiência Cardíaca
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article