Combination of Aryl Diselenides/Hydrogen Peroxide and Carbon-Nanotube/Rhodium Nanohybrids for Naphthol Oxidation: An Efficient Route towards Trypanocidal Quinones.
Chemistry
; 24(57): 15227-15235, 2018 Oct 12.
Article
em En
| MEDLINE
| ID: mdl-29904959
ABSTRACT
This work reports a combination of aryl diselenides/hydrogen peroxide and carbon-nanotube (CNT)/rhodium nanohybrids (RhCNT) for naphthol oxidation towards the synthesis of 1,4-naphthoquinones and evaluation of their relevant trypanocidal activity. Under a combination of (PhSe)2 /H2 O2 in the presence of O2 in iPrOH/hexane, several benzenoid (A-ring)-substituted quinones were prepared in moderate to high yields. We also studied the contribution of RhCNT as co-catalyst in this process and, in some cases, yields were improved. This method provides an efficient and versatile alternative for preparing A-ring-modified naphthoquinonoid compounds with relevant biological profile.
Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ródio
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Tripanossomicidas
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Naftoquinonas
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Nanotubos de Carbono
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Peróxido de Hidrogênio
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Naftóis
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article