Establishing the Production of Male Schistosoma mansoni Cercariae for a Controlled Human Infection Model.
J Infect Dis
; 218(7): 1142-1146, 2018 08 24.
Article
em En
| MEDLINE
| ID: mdl-29905805
ABSTRACT
To accelerate the development of novel vaccines for schistosomiasis, we set out to develop a human model for Schistosoma mansoni infection in healthy volunteers. During natural infections, female schistosomes produce eggs that give rise to morbidity. Therefore, we produced single-sex, male Schistosoma mansoni cercariae for human infection without egg production and associated pathology. Cercariae were produced in their intermediate snail hosts in accordance with the principles of good manufacturing practice (GMP). The application of GMP principles to an unconventional production process is a showcase for the controlled production of complex live challenge material in the European Union or under Food and Drug Administration guidance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Schistosoma mansoni
/
Esquistossomose
/
Caramujos
/
Esquistossomose mansoni
Tipo de estudo:
Guideline
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article